FlowSyn Publications

The Hofman rearrangement of amides into their corresponding carbamates works well under flow-through conditions. [Alessandro Palmieri, Steven V. Ley, Kelvin Hammond, Anastasios Polyzos, Ian R. Baxendale, Tetrahedron Lett., 2009, 50, 3287-3289].

A continuous flow-through approach to alpha-keto esters has been reported that utilises a combination of supported reagents to deliver products in high yield and purity with out the need for further purification. [Alessandro Palmieri, Steven V. Ley, Anastasios Polyzos, Mark Ladlow, Ian R. Baxendale, Beilstein J. Org. Chem., 2009, 5, No. 23]

A readily scalable synthesis of BDA protected tartrates has been reported by a continuous flow-through strategy utilising immobilised reagents and scavengers packed into reactor columns. [Catherine F. Carter, Ian R. Baxendale, Matthew O Brien, John B. J. Pavey, Steven V. Ley, Org. Biomol. Chem., 2009, 7, 4594-4597].