Flow chemistry applications
Below you will find examples of some of the chemistry which can be performed on the FlowSyn continuous flow reactor as well as a reference list of other sources in connection with flow chemistry.
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FlowSyn Optimisation and Scale Up
An introduction to reaction optimization and scale up using the Uniqsis FlowSyn. Reactions are optimized on a small scale using 2.5ml reactors. 8-fold increased throughput is achieved using a 20ml reactor.
FlowSyn Application note 1: SNAR Reaction
Reaction optimization to demonstration the effect of temperature on a simple SNAR reaction using the Uniqsis FlowSyn. Synthesis was performed using optimized conditions. Throughput of 41g/day achievable.
FlowSyn Application note 2: Ester Hydrolysis
The Ester Hydrolysis reaction was optimized using various temperatures, reaction times and stoichiometry. The reaction was scaled up to provide 92% yield and 105g/day throughput.
FlowSyn Application note 3: Knorr Pyrazole Synthesis
Flow optimization was used to investigate the effects of temperature and residence time. Scale up of these conditions afforded 84% yield of the product with a throughput of 261g/day.
FlowSyn™ Application Note 4: Esterification
FlowSyn™ Application Note 5: Esterification (2)
FlowSyn™ Application Note 6: 2-Thiobenzimidazolinone Synthesis
FlowSyn™ Application Note 6: 2-Thiobenzimidazolinone Synthesis
Poster- Flow Synthesis: Reaction Optimisation and Scale-up in Meso-reactors
Please download the poster which was presented at the Pittcon exhibition/conference 2008 in New Orleans.
Poster- FlowSyn: An Integrated Bench-top Continuous Flow Reactor
Please download the poster which was presented at the Pittcon exhibition/conference 2008 in New Orleans.
FlowSyn™ Application Note 8: Scale-up Synthesis of a Zyvox™ Intermediate
Zyvox™ (Upjohn) was the first example of a new class of oxazolidinone antibiotics that are active against MRSA. In this example, the scale-up abilities of FlowSyn™ are demonstrated by performing the first step in a possible synthesis of this compound on a
FlowSyn™ Application Note 7: Hantzsch 1,4-Dihydropyridine Synthesis
Hantzsch 1,4-Dihydropyridine Synthesis
Click here to see a list of more flow chemistry applications